In this project, after adding all details from the PubMed article at link in document using the gene expression data of a portion of the research article on primary nasopharyngeal carcinoma (NPC) and the gene KDM5B and its signature EBVIR-enhancer-KDM5B that allows interacting regions of the chromatin to become hijacked and the latent type II Epstien-Barr Virus (EBV) to take over and make NPC rapidly progress to tumor creation, NPC cell proliferation, and rapid decline more likely. In it they discuss that there are 2 created substances of JQ1 and GSK-467 that can knockout the KDM5B gene and suppress tumor proliferation by EBV. This analysis looks at 10 of the genes in the study mentioned and confirms their upregulation with upregulation of KDM5B using fold change values in MET vs nonMET samples they provided of 28 of the 177 samples. But in using a random forest model to predict 3 classes of MET, nonMET, or Normal, these 10 genes predicted with 28% accuracy overall, while top 20 genes of highest foldchange predicted 58% accuracy, and all 30 genes predicted 71% accuracy. Certain classes with all 30 genes were predicted with 100% accuracy in the Normal and the nonMET classes.

SurveyS3Statistika

2_Evaluaciones_Hojas_Manuscritas_2_Est_G_1